Following multiple dose administration, donepezil accumulates in plasma by 4-7 fold, and steady state is reached within 15 days
Donepezil's most common side effects are gastrointestinal, i
Pregnancy, breastfeeding and fertility
Donepezil hydrochloride, a piperidine derivative, is a centrally acting, rapid, and reversible acetylcholinesterase inhibitor
Continue to take donepezil even if you feel well
It has also been reported to mediate a reduction in delirium
Pregnancy
Among people with Alzheimer's disease without COVID-19, all-cause 30-day mortality was 5% (189/4189) for people taking donepezil compared with 7%
To assess the clinical efficacy and safety of donepezil in people with mild, moderate or severe dementia due to Alzheimer's disease; to compare the efficacy and
The effects of donepezil in Alzheimer's disease – results from a multinational trial
Donepezil is available as a regular tablet (Aricept), an orally disintegrating tablet (Aricept
irregular heartbeat
It can also help with mixed dementia
Fixed-combination preparation containing memantine and donepezil (Namzaric): Swallow capsules intact (do not divide, chew, or crush); alternatively, may open capsules, sprinkle on applesauce, and swallow without chewing
The most common side effects associated with donepezil are headache, generalized pain, fatigue, dizziness, nausea, vomiting, diarrhea, loss of appetite, weight loss, muscle cramping, joint pain, insomnia, and increased
Of the total drug interactions, 11 are major, 334 are moderate, and 129 are minor
Donepezil will not cure Alzheimer's disease, and it will not stop the disease from getting worse
Keep taking your donepezil every day, unless your doctor tells you to stop
St John's wort, a herbal remedy used for depression, can lower the levels of donepezil in your blood
Donepezil, a drug for Alzheimer For example, during the pivotal trials of donepezil, patients randomized to donepezil 10 mg day −1 received donepezil 5 mg day −1 for the first 7 days and then 10 mg day −1 thereafter
Dementia is a condition of the brain which causes a gradual loss of mental ability
This medication is an enzyme blocker that works by restoring the balance of natural substances (neurotransmitters) in the brain
Acetylcholinesterase inhibitors, such as donepezil, work by Common side effects
Side effects are less likely to happen if your doctor starts you on the lower 5mg dose for at least a month